Chapter 6

Are There Fragile Regions In the Human Genome?

 

Lesson 6.1

Of Mice and Men

 

Lesson 6.2

The Random Breakage Model of Chromosome Evolution

 

Sorting By Reversals

Lesson 6.3

 

Lesson 6.4

A Greedy Algorithm for Sorting By Reversals

 

Breakpoints

Lesson 6.5

 

Rearrangements in Tumor Genomes

Lesson 6.6

 

From Unichromosomal to Multichromosomal Genomes

Lesson 6.7

 

Breakpoint Graphs

Lesson 6.8

 

Computing the 2-Break Distance

Lesson 6.9

 

Rearrangement Hotspots in the Human Genome

Lesson 6.10

 

Synteny Block Construction

Ch. 6 Epilogue

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© 2020 by Phillip Compeau & Pavel Pevzner    |    All Rights Reserved    |    ISBN: 978-0-9903746